abstract：:Evidence is presented that a single injection of bacterial antigen in oil into a footpad of rats of 5 strains induced different clinical forms of adjuvant disease in the individual rat strains. Rats were injected with 300 micrograms heat-killed Mycobacterium tuberculosis in 50 microliters paraffin. Inflammatory lesion...

journal_title：Annals of the rheumatic diseases

authors： Muir VY,Dumonde DC

更新日期：1982-10-01 00:00:00

abstract：:The relationship between the tensile properties of articular cartilage and age has been investigated in vitro in the human knee joint. Specimens orientated parallel to the articular surface were excised from the superficial and deep zones of the femoral condyles of knee joints of persons in the age range from 8 to 91 ...

journal_title：Annals of the rheumatic diseases

authors： Kempson GE

更新日期：1982-10-01 00:00:00

abstract：:105 consecutive patients who presented to a rheumatologist because of joint disease and who also had evidence of deposition of calcium pyrophosphate dihydrate (CPD) were studied clinically and radiologically. There were 76 women (mean age 73) and 29 men (mean age 62). Of only 18 patients below the age of 60 at present...

journal_title：Annals of the rheumatic diseases

authors： Dieppe PA,Alexander GJ,Jones HE,Doherty M,Scott DG,Manhire A,Watt I

更新日期：1982-08-01 00:00:00

abstract：:Three aspects of polymorphonuclear leucocyte (PMN) function were studied in 19 patients with Behçet's syndrome (BS). By 2 different techniques directed motility was found to be increased. This increase was largely due to the subgroup of patients with ocular involvement. Counts of absolute numbers of cells migrating hi...

journal_title：Annals of the rheumatic diseases

authors： Fordham JN,Davies PG,Kirk A,Currey HL

更新日期：1982-08-01 00:00:00

abstract：:The 13 questions to which 173 rheumatic outpatients most frequently wished to know the answer were made the basis of a structured interview. Two lengths of interview were conducted in a controlled trial (short being of 2 minutes' duration, long ranging from 4 to 11 minutes). Sixty patients referred directly from their...

journal_title：Annals of the rheumatic diseases

authors： Wright V,Hopkins R,Burton K

更新日期：1982-06-01 00:00:00

abstract：:During 1978 a survey was carried out on 34 036 people in Nagano Prefecture, Japan, in an epidemiological study of hyperuricaemia; 15 713 males and 18 324 females were examined by means of our health examination car. The subjects of the survey were all volunteers. The results have shown that the serum uric acid (SUA) l...

journal_title：Annals of the rheumatic diseases

authors： Akizuki S

更新日期：1982-06-01 00:00:00

abstract：:A nephelometric assay of concanavalin-A binding of serum acute phase proteins (con-A binding) has been used in cross-sectional and sequential studies of disease activity in rheumatoid arthritis (RA). Con-A binding correlated well with blood viscosity, C-reactive protein, and other individual acute phase reactants in p...

journal_title：Annals of the rheumatic diseases

authors： Martin MF,Dieppe PA,Jones HE,Warren C,Whicher J,Kohn J

更新日期：1982-04-01 00:00:00

abstract：:Serum C2 activity was measured in 135 individuals drawn from a panel of 418 tissue-typed blood donors. The study group included all donors with HLA antigens A10 and B18. Heterozygote C2 deficiency (C2Dhet) was defined by reference to the range of C2 activity in previously studied obligate heterozygotes. Five donors we...

journal_title：Annals of the rheumatic diseases

authors： Rynes RI,Britten AF,Pickering RJ

更新日期：1982-02-01 00:00:00

abstract：:Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less. Eleven cases of ocular toxicity attributed to chloroquine were report...

journal_title：Annals of the rheumatic diseases

authors： Marks JS

更新日期：1982-02-01 00:00:00

abstract：:Plasma DNA has been measured by a new physiochemical approach based on fluorimetric analysis of phenol extracted nucleic acids electrophoresed on polyacrylamide gels. This method is specific for native double-stranded DNA of molecular weight greater than 5 x 10(6). The use of plasma rigorously freed of leucocytes is e...

journal_title：Annals of the rheumatic diseases

authors： Klemp P,Meyers OL,Harley EH

更新日期：1981-12-01 00:00:00

abstract：:Arthro-osteitis at the anterior chest wall was found in 12 (9.4%) out of 128 consecutive patients with pustulosis palmaris et plantaris. This finding indicates that the concomitance of arthro-osteitis with PPP is not incidental but is based on some common aetiological factor. We propose a term ;pustulotic arthro-ostei...

journal_title：Annals of the rheumatic diseases

authors： Sonozaki H,Kawashima M,Hongo O,Yaoita H,Ikeno M,Matsuura M,Okai K,Azuma A

更新日期：1981-12-01 00:00:00

abstract：:Circulating immune complexes (CIC) were measured in 4 normal controls and 8 patients with systemic lupus erythematosus (SLE) by a polyethylene glycol precipitation (PEG) method during a 24-hour period. In all the normal controls levels fell during sleep and after drinking 1 pint (568 ml) of milk and rose before gettin...

journal_title：Annals of the rheumatic diseases

authors： Isenberg DA,Crisp AJ,Morrow WJ,Newham D,Snaith ML

更新日期：1981-10-01 00:00:00

abstract：:A method is described for evaluating the progress of patients with back pain. Various symptoms were scored on analogue scales and spinal motion was measured by various techniques. These data were integrated to make subjective and objective indices respectively. Reasonable reproducibility of the measurements was obtain...

journal_title：Annals of the rheumatic diseases

authors： Million R,Nilsen KH,Jayson MI,Baker RD

更新日期：1981-10-01 00:00:00

abstract：:The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9....

journal_title：Annals of the rheumatic diseases

authors： Tokunaga M,Ohuchi K,Yoshizawa S,Tsurufuji S,Rikimaru A,Wakamatsu E

更新日期：1981-10-01 00:00:00

abstract：:A simple method is described which allows sequential monitoring of the endocytic activity of blood and synovial fluid cells from rheumatoid arthritis patients undergoing therapy with levamisole. Evidence of immediate (24 hours) and long-term (5-7 weeks) cellular phagocytic enhancement is presented. ...

journal_title：Annals of the rheumatic diseases

authors： Wynne KM,Dieppe PA,Scott J,Huskisson EC

更新日期：1981-08-01 00:00:00

abstract：:Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients...

journal_title：Annals of the rheumatic diseases

authors： McInnes GT,Lawson DH,Jick H

更新日期：1981-06-01 00:00:00

abstract：:The aetiology of Reiter's syndrome (RS) is unknown. In order to evaluate the role of immunological mechanisms in this disease we performed synovial biopsies on 12 patients with RS looking for deposition of immunoglobulins and complement components in synovial tissue. By immunofluorescent techniques 11 synovia were fou...

journal_title：Annals of the rheumatic diseases

authors： Baldassare AR,Weiss TD,Tsai CC,Arthur RE,Moore TL,Zuckner J

更新日期：1981-06-01 00:00:00

abstract：:A 33-year-old male with definite Behçet's disease had rheumatoid-like nodules at his elbows. This finding, we believe, represents another manifestation of vasculitis in Behçet's disease. ...

journal_title：Annals of the rheumatic diseases

authors： Yurdakul S,Yazici H,Tüzüner N,Aytac S,Müftüoğlu AU

更新日期：1981-04-01 00:00:00

abstract：:Reproducibility along a vertical 10 cm visual analogue scale (VAS) was investigated. Eight normal volunteers attempted to duplicate a set of marked VAS. There was a tendency to estimate too high on the scale, and reproducibility was found to be variable along its length. This indicates that the error involved in the u...

journal_title：Annals of the rheumatic diseases

authors： Dixon JS,Bird HA

更新日期：1981-02-01 00:00:00

abstract：:An investigation of cell-mediated cytotoxicity in 22 patients with systemic lupus erythematosus (SLE), using both whole blood and purified peripheral blood mononuclear cells (PBM) to measure antibody-dependent (ADCC) and phytohaemagglutinin (PHA)-induced lymphocyte cytotoxicity for Chang liver cells, has revealed 2 di...

journal_title：Annals of the rheumatic diseases

authors： Wright JK,Hughes P,Gelsthorpe K,Ward AM,Rowell NR

更新日期：1981-02-01 00:00:00

abstract：:Serum immunoglobulins were measured in 122 patients with ankylosing spondylitis (AS) during various phases of disease activity and compared to those in 58 healthy subjects. The mean serum IgA was 38% higher in patients (306.9 mg/dl) than in controls (222.7 mg/dl) (P < 0.005), but there was no significant difference in...

journal_title：Annals of the rheumatic diseases

authors： Cowling P,Ebringer R,Ebringer A

更新日期：1980-12-01 00:00:00

abstract：:Atlanto-axial subluxation occurs with a frequency varying from 6% to 45% in rheumatoid arthritis. Most patients are treated conservatively with a cervical collar. The effectiveness of different cervical collars in inhibiting anterior atlanto-axial subluxation was tested in 11 patients with classical rheumatoid arthrit...

journal_title：Annals of the rheumatic diseases

authors： Althoff B,Goldie IF

更新日期：1980-10-01 00:00:00

abstract：:We have compared the distribution of histocompatibility antigens of 22 Turkish and 14 British patients with Behçet's disease with those of their respective controls. There was a strong association of B5, specifically its Bw51 split, with the disease. A modest increase in the incidence of HLA B27 was noted in British p...

journal_title：Annals of the rheumatic diseases

authors： Yazici H,Chamberlain MA,Schreuder I,D'Amaro J,Muftuoglu M

更新日期：1980-08-01 00:00:00

abstract：:Arthralgias have previously been reported in association with acne fulminans, but the following case in the first report of osseous lesions associated with this disease. The destructive bony lesion was rapid in onset but self-limited. ...

journal_title：Annals of the rheumatic diseases

authors： Hunter LY,Hensinger RN

更新日期：1980-08-01 00:00:00

abstract：:An acute inflammatory arthritis has been induced in 76% of rats injected intradermally with native bovine type II collagen emulsified in Freund's complete (CFA) or incomplete (ICFA) adjuvant. The arthritis became chronic in 14 out of 31 rats, and ear and tail lesions were noted in some rats. No arthritis was induced b...

journal_title：Annals of the rheumatic diseases

authors： Morgan K,Clague RB,Shaw MJ,Holt PJ

更新日期：1980-06-01 00:00:00

abstract：:The adherent cells remaining after short-term culture of synovial fluid and synovial membrane cells from rheumatoid and non-rheumatoid patients were examined for the presence of a productive virus infection and for various viral antigens. Labelling was carried out with 3H-thymidine and 3H-uridine followed by sucrose d...

journal_title：Annals of the rheumatic diseases

authors： Hart H,Norval M

更新日期：1980-04-01 00:00:00

abstract：:Human extensor tendons of the hand were pulled to rupture, and the torn ends, when observed in the scanning electron microscope, appeared to be knotted, possibly owing to the denaturation of the collagen. This confirmed by fluorimetry assays of both the ruptured ends and the middle unbroken sections of the same tendon...

journal_title：Annals of the rheumatic diseases

authors： Minns RJ,Steven FS

更新日期：1980-04-01 00:00:00

abstract：:Adult human articular cartilage has been maintained in organ culture for 8 days, and the culture medium, which was changed on alternate days, was pooled. Normal and rheumatoid cartilage was obtained from patients and 4 types of culture were prepared: (1) cartilage alone; (2) cartilage + D-penicillamine; (3) cartilage ...

journal_title：Annals of the rheumatic diseases

authors： Jacoby RK

更新日期：1980-02-01 00:00:00

abstract：:A case is reported of polytenosynovitis in a 31-year-old male during the course of a severe bacteraemic illness caused by Haemophilus influenzae type b. The clinical presentation was similar to tenosynovitis caused by bacterial or viral agents. As the management of the H. influenzae tenosynovitis would differ from tha...

journal_title：Annals of the rheumatic diseases

authors： Bansal S,Magnussen CR,Napodano RJ

更新日期：1979-12-01 00:00:00

abstract：:Symptomatic osteonecrosis occurred in 8 out of 68 patients with systemic lupus erythematosus. Multiple joints were involved in 3 patients, and weight-bearing joints were most frequently affected. Osteonecrosis tended to occur early in the disease, and the patients had all received corticosteroids. Symptoms tended to o...

journal_title：Annals of the rheumatic diseases

authors： Griffiths ID,Maini RN,Scott JT

更新日期：1979-10-01 00:00:00

abstract：:A patient with rheumatoid arthritis (RA), vasculitis, and aortic valve incompetence of the histologically nonspecific type is described. Valve replacement was undertaken, and an excellent haemodynamic result was achieved. Both arthritis and vasculitis subsequently remitted. Valve replacement can be successfully perfor...

journal_title：Annals of the rheumatic diseases

authors： Liew M,Wilson D,Horton D,Fleming A

更新日期：1979-10-01 00:00:00

abstract：:Dense, granular immunoglobulin deposits have been identified at the epidermo-dermal junction in 4 out of 10 patients who developed toxic reactions to D-penicillamine therapy for rheumatoid arthritis. Three of 4 patients developing a lupus-like syndrome while on penicillamine had similar findings on skin biopsy. Serum ...

journal_title：Annals of the rheumatic diseases

authors： Kirby JD,Dieppe PA,Huskisson EC,Smith B

更新日期：1979-08-01 00:00:00

abstract：:Serum C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were compared in 241 patients with rheumatoid arthritis (RA). There was a positive linear correlation between the 2 measurements with a high degree of variability. Neither age nor duration of RA had a detectable influence. The relationship bet...

journal_title：Annals of the rheumatic diseases

authors： Walsh L,Davies P,McConkey B

更新日期：1979-08-01 00:00:00

abstract：:Information has been collected on 10 patients, 9 with marrow depression and 1 in whom the diagnosis was presumed. Six of the 10 patients died. The sequentially recorded blood counts on at least 5 of the patients showed a downward trend of the white cell and platelet counts while D-penicillamine was still being adminis...

journal_title：Annals of the rheumatic diseases

authors： Kay AG

更新日期：1979-06-01 00:00:00

abstract：:While rheumatoid-factor-producing haemolytic plaque-forming cells (RF--PFC) of the human peripheral blood were easily inhibited by cycloheximide, mouse spleen cells immune to sheep red cells (anti-SRC PFC) were inhibited only after prolonged preincubation in the drug. The RF--PFC were easily inhibited by propranolol, ...

journal_title：Annals of the rheumatic diseases

authors： Moore TL,Rose JE,Vaughan JH

更新日期：1979-06-01 00:00:00

abstract：:A family with features of the mucocutaneous ocular syndrome is described. A 4-generation study reveals that the condition has been inherited as an autosomal dominant trait with variable expressivity. Psychiatric symptoms and myalgia have been prominent features peculiar to our patients. ...

journal_title：Annals of the rheumatic diseases

authors： Berman L,Trappler B,Jenkins T

更新日期：1979-04-01 00:00:00

abstract：:Naproxen at 10 mg per kg body weight was compared with aspirin at 80 mg per kg body weight in children suffering from juvenile chronic polyarthritis. It was found to be as effective as aspirin, with certainly no more and possibly fewer gastrointestinal side effects. A long-term tolerance study up to 12 months confirme...

journal_title：Annals of the rheumatic diseases

authors： Moran H,Hanna DB,Ansell BM,Hall M,Engler C

更新日期：1979-04-01 00:00:00

abstract：:In order to evaluate the incidence and aetiology of hypergastrinaemia 53 patients with seropositive rheumatoid arthritis were examined for gastric acid secretion, fasting serum gastrin concentration, circulating parietal cell antibodies, and some parameters of the activity of inflammation of rheumatoid arthritis. The ...

journal_title：Annals of the rheumatic diseases

authors： de Witte TJ,Geerdink PJ,Lamers CB,Boerbooms AM,van der Korst JK

更新日期：1979-02-01 00:00:00

abstract：:HLA A, B, and C antigens were studied in 25 patients with ankylosing hyperostosis. There was no evidence of an increased frequency of any antigen in association with the condition itself. However, a high frequency of several antigens was found, reflecting the predominance of Jewish patients in the series. ...

journal_title：Annals of the rheumatic diseases

authors： Perry JD,Wolf H,Festenstein H,Storey GO

更新日期：1979-02-01 00:00:00

abstract：:Chondromalacia patellae is difficult to diagnosis clinically with accuracy. In order to clarify the relevant symptoms and signs, 78 patients presenting with a clinical diagnosis of chondromalacia were examined by arthroscopy. In 49% of the knees no abnormalities were found. Presenting symptoms were similar in the norm...

journal_title：Annals of the rheumatic diseases

authors： Leslie IJ,Bentley G

更新日期：1978-12-01 00:00:00